Common name for more than 1,000 species of flowering plants in the family Convolvulaceae
Morning glory flower, Ipomoea nil
An unopened spiral bud of a morning glory flower, Ipomoea purpurea
'Blue Star', a cultivar of Ipomoea tricolor photographed in Haverhill, Massachusetts
Morning glory flower (Ipomoea purpurea )
Morning glory (also written as morning-glory [ 1] ) is the common name for over 1,000 species of flowering plants in the family Convolvulaceae , whose current taxonomy and systematics are in flux. Morning glory species belong to many genera , some of which are:
As the name suggests, most morning glory flowers unfurl into full bloom in the early morning. The flowers usually start to fade a few hours before the corolla begins to display visible curling. They prefer full solar exposure throughout the day, and mesic soils. Some morning glories, such as Ipomoea muricata , Ipomoea alba , and Ipomoea macrorhiza , are night-blooming flowers.
Ipomoea purpurea in Loganville, Georgia
Ipomoea nil , a species of morning glory, was first known in China for its medicinal uses, due to the laxative properties of its seeds.
Ancient Mesoamerican civilizations used the morning glory species Ipomoea alba to convert the latex from the Castilla elastica tree and also the guayule plant to produce bouncing rubber balls.[ 2] The sulfur in the morning glory's juice served to vulcanize the rubber, a process antedating Charles Goodyear 's discovery by at least 3,000 years.[ 3] Aztec priests in Mexico were also known to use the plant's hallucinogenic properties (see Rivea corymbosa ).
In some places, such as Australian bushland, some species of morning glories develop thick roots and tend to grow in dense thickets. They can quickly spread by way of long, creeping stems. By crowding out, blanketing, and smothering other plants, morning glory has turned into a serious invasive weed problem.[ 4]
In parts of the US, species such as Calystegia sepium (hedge bindweed), Ipomoea purpurea (common morning glory) and Ipomoea indica (blue morning glory) have shown to be invasive. In fact, as of 2021, most non-native species of Ipomoea are currently illegal to cultivate, possess, and sell in the U.S. state of Arizona , and before 4 January 2020, this ban applied to native species, too. This is because some species of Convolvulaceae (like Convolvulus arvensis and Ipomoea × leucantha ) have been known to cause problems in crops, especially in cotton fields.[ 5] [ 6] Ipomoea aquatica is a federal noxious weed, though some states, like Texas, have acknowledged its status as a vegetable and allow it to be grown.[ 7] [ 8]
In cultivation, most are treated as perennial plants in frost-free areas and as annual plants in colder climates, but some species tolerate winter cold. Some species are strictly annual (e.g. Ipomoea nil ), producing many seeds, and some perennial species (e.g. I. indica ) are propagated by cuttings. Some moonflowers , which flower at night, are also in the morning glory family.
Because of their fast growth, twining habit, attractive flowers, and tolerance for poor, dry soils, some morning glories are excellent vines for creating summer shade on building walls when trellised, thus keeping the building cooler and reducing heating and cooling costs.
Popular varieties in contemporary western cultivation include 'Sunspots' , 'Heavenly Blue' , moonflower, cypress vine , and cardinal climber . The cypress vine is a hybrid, with the cardinal climber as one parent.
Many morning glories self-seed in the garden. They have a hard seed coat, which delays germination until late spring. Germination may be improved by soaking in warm water.[ 9]
Morning glory has been a favorite flower in Japan for many a long century.[ 10] The cultivation started in the Nara period (8th century).[ 10] The big booms of the selective breeding of the morning glory happened in the Edo era (17-19th century).[ 10] The large-flowered morning glory was broadly cultivated as a hobby flower. The varied Japanese morning glory (変化朝顔 Henka-asagao or mutant morning glory) was created.[ 10] [ 11]
Stereo image Parallel view ( )
Cross-eye view ( )
Morning glory seeds, mixed colors
Ipomoea aquatica , known as water spinach, water morning glory, water convolvulus, ong-choy, kang-kung , or swamp cabbage, is popularly used as a green vegetable, especially in East and Southeast Asian cuisines . In the US, I. aquatica is a federal noxious weed , and can be illegal to grow, import, possess, or sell without a permit. A market exists, though, for the plant's powerful culinary potential.[ 8] As of 2005, the state of Texas has acknowledged that water spinach is a highly prized vegetable in many cultures, and has allowed it to be grown for personal consumption, in part because it is known to have been grown in Texas for more than 15 years and has not yet escaped cultivation.[ 7]
The genus Ipomoea also contains the sweet potato (I. batatas ). Though the term "morning glory" is not usually extended to I. batatas , sometimes it may be referred to as a "tuberous morning glory" in a horticultural context. Some cultivars of I. batatas are grown for their ornamental value, rather than for the edible tuber.
Chemistry and ethnobotany [ edit ]
The seeds of many species of morning glory contain ergoline alkaloids such as the psychoactive and/or psychedelic lysergamides ergine (lysergic acid amide; LSA) and isoergine (isolysergic acid amide; iso-LSA), which are closely structurally related to lysergic acid diethylamide (LSD).[ 12] [ 13] [ 14] Seeds of Ipomoea tricolor and Turbina corymbosa (syn. R. corymbosa ) are used as psychedelics .[ 15] The seeds of morning glory can produce similar effects to LSD when ingested in sufficient numbers, often numbering into the hundreds. Though the chemicals ergine and isoergine are not legal in some countries, the seeds are found in many gardening stores; however, some claim the seeds from commercial sources can sometimes be coated in some kind of pesticide or methylmercury (although the latter is illegal in the UK and the US).[ 16] The onset is 20 to 180 minutes and the duration is 4 to 10 hours.[ 17] Previously thought to be exclusively synthetic compounds , methylergometrine and methysergide have also been reported to occur in Argyreia nervosa .[ 12] [ 18]
^ BSBI List 2007 (xls) . Botanical Society of Britain and Ireland . Archived from the original (xls) on 2015-06-26. Retrieved 2014-10-17 .
^ Hosler, Dorothy; Burkett, Sandra L.; Tarkanian, Michael J. (18 June 1999). "Prehistoric Polymers: Rubber Processing in Ancient Mesoamerica" . Science . 284 (5422): 1988– 1991. doi :10.1126/science.284.5422.1988 . PMID 10373117 . Archived from the original on 25 October 2021. Retrieved 25 October 2021 – via science.org (Atypon).
^ "Rubber processed in ancient Mesoamerica, MIT researchers find" . News.mit.edu . 14 July 1999. Archived from the original on 25 October 2021. Retrieved 25 October 2021 .
^ "Archived copy" (PDF) . Archived from the original (PDF) on 2017-03-29. Retrieved 2020-03-24 .{{cite web }}
: CS1 maint: archived copy as title (link )
^ "Why We Can't Sell Native Morning Glories" . Desertsurvivors.org . Archived from the original on 2021-09-03. Retrieved 2021-09-03 .
^ "The Curious Case of Arizona's Morning Glories (Ipomoea spp.)" (PDF) . Archived (PDF) from the original on 2020-11-26. Retrieved 2021-09-03 .
^ a b "Texas Register - The Portal to Texas History" . The Portal to Texas History . Archived from the original on 2007-07-26. Retrieved 2018-08-17 .
^ a b "USDA weed factsheet" (PDF) . Aphis.usda.gov . Archived (PDF) from the original on 12 June 2012. Retrieved 25 October 2021 .
^ "How to Grow Morning Glories" . wikiHow . Archived from the original on 2021-10-03. Retrieved 2021-10-03 .
^ a b c d "The Japan Magazine A Representative Monthly of Things Japanese vol 7" S. Murayama, Japan magazine Company 1916, p175
^ くらしの植物苑特別企画「伝統の朝顔」 Archived 2022-02-18 at the Wayback Machine National Museum of Japanese History.
^ a b Chen W, De Wit-Bos L (2020). Risk assessment of Argyreia nervosa (PDF) (Report). doi :10.21945/rivm-2019-0210 .
^ Shulgin AT (1976). "Psychotomimetic Agents". In Gordon M (ed.). Psychopharmacological Agents: Use, Misuse and Abuse . Medicinal Chemistry: A Series of Monographs. Vol. 4. Academic Press. p. 59–146. doi :10.1016/b978-0-12-290559-9.50011-9 . ISBN 978-0-12-290559-9 .
^ Brimblecombe RW, Pinder RM (1975). "Indolealkylamines and Related Compounds". Hallucinogenic Agents . Bristol: Wright-Scientechnica. pp. 98– 144. ISBN 978-0-85608-011-1 . OCLC 2176880 . OL 4850660M .
^ Vargas, Theresa (2006-05-03). "A '60s Buzz Recycled" . The Washington Post . Archived from the original on 2011-01-23. Retrieved 2010-05-13 .
^ Johnnson, Timothy (1999). CRC Ethnobotany Desk Reference . CRC Press. p. 431. ISBN 0-8493-1187-X .
^ Tittarelli R, Mannocchi G, Pantano F, Romolo FS (January 2015). "Recreational use, analysis and toxicity of tryptamines" . Curr Neuropharmacol . 13 (1): 26– 46. doi :10.2174/1570159X13666141210222409 . hdl :11573/874462 . PMID 26074742 . Ergine, or lysergic acid amide (LSA), is an alkaloid of the ergoline family closely related to LSD, found in the seeds of Argyreia nervosa (Hawaiian baby woodrose) and Ipomoea violacea (Morning Glories). Hallucinogenic activity of LSA occurs with 4-10 seeds of Argyreia nervosa or with 150–200 seeds (3–6 g) of Ipomoea violacea: seeds could be crushed or eaten whole, or also drunk as an extract, after soaking in water [42]. The onset of the hallucinatory effects, after ingestion of Hawaiian Baby Woodrose, is from 20 to 40 minutes and their total duration is from 5 to 8 hours: the plateau is reached after 4-6 hours and the return to normality is after 1-2 hours from the plateau. [...] However, as regards to the assumption of the Morning Glory seeds, the onset of the hallucinatory effects is from 30 to 180 minutes and they last for 4 to 10 hours. The users reported that they return to normality after about 24 hours [67].
^ Paulke A, Kremer C, Wunder C, Wurglics M, Schubert-Zsilavecz M, Toennes SW (April 2015). "Studies on the alkaloid composition of the Hawaiian Baby Woodrose Argyreia nervosa, a common legal high". Forensic Sci Int . 249 : 281– 293. doi :10.1016/j.forsciint.2015.02.011 . PMID 25747328 .
Everitt, J.H.; Lonard, R.L.; Little, C.R. (2007). Weeds in South Texas and Northern Mexico . Lubbock: Texas Tech University Press. ISBN 978-0-89672-614-7 .
Furst, Peter (1990). Flesh of the Gods . ISBN 978-0-88133-477-7 .
Schultes, Richard Evans (1976). Hallucinogenic Plants . Elmer W. Smith, illustrator. New York: Golden Press. ISBN 0-307-24362-1 .
No ring subs. 4-Hydroxytryptamines 5-Hydroxytryptamines 5-Methoxytryptamines Other ring subs.
2,N ,N -TMT
4,N ,N -TMT
5-Bromo-DMT
5-N ,N -TMT
7,N ,N -TMT
5-Fluoro-DMT
5-Me-MiPT
5-MeO-2,N ,N -TMT
5-MeO-4,N ,N -TMT
6-Fluoro-DMT
α-Alkyltryptamines Others
Ergolines /lysergamides (e.g., LSD )
Harmala alkaloids and β-carbolines (e.g., harmaline )
Iboga alkaloids (e.g., 18-MAC , 18-MC , coronaridine , ibogaine , ibogamine , ME-18-MC , noribogaine , tabernanthine , voacangine )
Ibogalogs (e.g., ibogainalog )
Partial ergolines (e.g., NDTDI , RU-28306 , DEIMDHPCA , CT-5252 )
Piperidinylethylindoles (e.g., Pip-T )
Pyrrolidinylethylindoles (e.g., Pyr-T , 5-MeO-pyr-T )
Pyrrolidinylmethylindoles (e.g., MPMI , 4-HO-MPMI (lucigenol) , 5-MeO-MPMI )
Others: 2C-G-x (e.g., 2C-G-3 , 2C-G-5
β-Keto-2C-B (βk-2C-B)
β-Keto-2C-I (βk-2C-I)
β-Methyl-2C-B (BMB)
(e.g., BOB , BOD )
(e.g., HOT-2 , HOT-7 , HOT-17 )
N -Ethyl-2C-B
(e.g., 2CD-2-ETO , 2CD-5-ETO , 2CE-5-ETO , 2CE-5iPrO , 2CT2-5-ETO )
(NBOMes and related) Others
2-TOET
2-TOM
4-HA
5-TOET
5-TOM
Benzofurans (e.g., F-2 , F-22 )
Benzothiophenes (e.g., 5-APBT , 6-APBT )
DMAs (e.g., 2,4-DMA , 3,4-DMA )
Fenfluramine
MMA (3-MeO-4-MA)
Norfenfluramine
(e.g., 25D-NM-NDEAOP , DOB-NDEPA , DOI-NDEPA , DOM-NDEPA , DOTFM-NDEPA , M-NDEPA , TMA-2-NDEPA )
PMA (4-MA)
(e.g., TMA-3 , TMA-4 , TMA-5 , TMA-6 )
TOMSO
ZDCM-04
1-Aminomethylindanes (e.g., 2CB-Ind , jimscaline )
2-Aminoindanes (e.g., DOM-AI )
2-Aminotetralins (e.g., DOM-AT )
3-Phenylpiperidines (e.g., LPH-5 , LPH-48 )
Benzazepines (e.g., lorcaserin )
Benzocyclobutenes (e.g., 2CBCB-NBOMe , TCB-2 , tomscaline )
DMBMPP (juncosamine)
Ergolines /lysergamides (e.g., LSD )
Glaucine
IHCH-7113
Partial ergolines (e.g., NDTDI , DEIMDHPCA , DEMPDHPCA , DEMTMPDHPCA , DEMNDHPCA )
Phenylcyclopropylamines (e.g., DMCPA , TMT )
Phenylmorpholines (phenmetrazines) (e.g., 2C-B-morpholine )
Phenyloxazolamines (aminorexes ) (e.g., 2C-B-aminorex )
Z3517967757
ZC-B
Others
5-HT1
5-HT1A
Agonists: 8-OH-DPAT
Adatanserin
Amphetamine
Antidepressants (e.g., etoperidone , hydroxynefazodone , nefazodone , trazodone , triazoledione , vilazodone , vortioxetine )
Atypical antipsychotics (e.g., aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , lurasidone , quetiapine , ziprasidone )
Azapirones (e.g., buspirone , eptapirone , gepirone , perospirone , tandospirone )
Bay R 1531
Befiradol
BMY-14802
Cannabidiol
Dimemebfe
Dopamine
Ebalzotan
Eltoprazine
Enciprazine
Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , lisuride , LSD , methylergometrine (methylergonovine) , methysergide , pergolide )
F-11,461
F-12826
F-13714
F-14679
F-15063
F-15,599
Flesinoxan
Flibanserin
Flumexadol
Hypidone
Lesopitron
LY-293284
LY-301317
mCPP
MKC-242
Naluzotan
NBUMP
Osemozotan
Oxaflozane
Pardoprunox
Piclozotan
Rauwolscine
Repinotan
Roxindole
RU-24,969
S-14,506
S-14671
S-15535
Sarizotan
Serotonin (5-HT)
SSR-181507
Sunepitron
Tryptamines (e.g., 5-CT , 5-MeO-DMT , 5-MT , bufotenin , DMT , indorenate , N-Me-5-HT , psilocin , psilocybin )
TGBA01AD
U-92,016-A
Urapidil
Vilazodone
Xaliproden
Yohimbine
Antagonists: Atypical antipsychotics (e.g., iloperidone , risperidone , sertindole )
AV965
Beta blockers (e.g., alprenolol , carteolol , cyanopindolol , iodocyanopindolol , isamoltane , oxprenolol , penbutolol , pindobind , pindolol , propranolol , tertatolol )
BMY-7,378
CSP-2503
Dotarizine
Ergolines (e.g., metergoline )
FCE-24379
Flopropione
GR-46611
Isamoltane
Lecozotan
Mefway
Metitepine (methiothepin)
MIN-117 (WF-516)
MPPF
NAN-190
Robalzotan
S-15535
SB-649,915
SDZ 216-525
Spiperone
Spiramide
Spiroxatrine
UH-301
WAY-100135
WAY-100635
Xylamidine
5-HT1B
Agonists: Anpirtoline
CGS-12066A
CP-93129
CP-94253
CP-122,288
CP-135807
Eltoprazine
Ergolines (e.g., bromocriptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide )
mCPP
RU-24,969
Serotonin (5-HT)
Triptans (e.g., avitriptan , donitriptan , eletriptan , sumatriptan , zolmitriptan )
TFMPP
Tryptamines (e.g., 5-BT , 5-CT , 5-MT , DMT )
Vortioxetine
5-HT1D
Agonists: CP-122,288
CP-135807
CP-286601
Ergolines (e.g., bromocriptine , cabergoline , dihydroergotamine , ergotamine , LSD , methysergide )
GR-46611
L-694247
L-772405
mCPP
PNU-109291
PNU-142633
Serotonin (5-HT)
TGBA01AD
Triptans (e.g., almotriptan , avitriptan , donitriptan , eletriptan , frovatriptan , naratriptan , rizatriptan , sumatriptan , zolmitriptan )
Tryptamines (e.g., 5-BT , 5-CT , 5-Et-DMT , 5-MT , 5-(nonyloxy)tryptamine , DMT )
5-HT1E
5-HT1F
5-HT2
5-HT2A
Agonists: 25H/NB series (e.g., 25I-NBF , 25I-NBMD , 25I-NBOH , 25I-NBOMe , 25B-NBOMe , 25C-NBOMe , 25TFM-NBOMe , 2CBCB-NBOMe , 25CN-NBOH , 2CBFly-NBOMe )
2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 )
2C-B-FLY
2CB-Ind
5-Methoxytryptamines (5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT )
α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT )
AL-34662
AL-37350A
Bromo-DragonFLY
Dimemebfe
DMBMPP
DOx (e.g., DOB , DOC , DOI , DOM )
Efavirenz
Ergolines (e.g., 1P-LSD , ALD-52 , bromocriptine , cabergoline , ergine (LSA) , ergometrine (ergonovine) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , methylergometrine (methylergonovine) , pergolide )
Flumexadol
IHCH-7113
Jimscaline
Lorcaserin
MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA )
O-4310
Oxaflozane
PHA-57378
PNU-22394
PNU-181731
RH-34
SCHEMBL5334361
Phenethylamines (e.g., lophophine , mescaline )
Piperazines (e.g., BZP , quipazine , TFMPP )
Serotonin (5-HT)
TCB-2
TFMFly
Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine )
Antagonists: 5-I-R91150
5-MeO-NBpBrT
AC-90179
Adatanserin
Altanserin
Antihistamines (e.g., cyproheptadine , hydroxyzine , ketotifen , perlapine )
AMDA
Atypical antipsychotics (e.g., amperozide , aripiprazole , asenapine , blonanserin , brexpiprazole , carpipramine , clocapramine , clorotepine , clozapine , fluperlapine , gevotroline , iloperidone , lurasidone , melperone , mosapramine , ocaperidone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , zicronapine , ziprasidone , zotepine )
Chlorprothixene
Cinanserin
CSP-2503
Deramciclane
Dotarizine
Eplivanserin
Ergolines (e.g., amesergide , LY-53857 , LY-215,840 , mesulergine , metergoline , methysergide , sergolexole )
Fananserin
Flibanserin
Glemanserin
Irindalone
Ketanserin
KML-010
Landipirdine
LY-393558
mCPP
Medifoxamine
Metitepine (methiothepin)
MIN-117 (WF-516)
Naftidrofuryl
Nantenine
Nelotanserin
Opiranserin (VVZ-149)
Pelanserin
Phenoxybenzamine
Pimavanserin
Pirenperone
Pizotifen
Pruvanserin
Rauwolscine
Ritanserin
Roluperidone
S-14671
Sarpogrelate
Serotonin antagonists and reuptake inhibitors (e.g., etoperidone , hydroxynefazodone , lubazodone , mepiprazole , nefazodone , triazoledione , trazodone )
SR-46349B
TGBA01AD
Teniloxazine
Temanogrel
Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine )
Tricyclic antidepressants (e.g., amitriptyline )
Typical antipsychotics (e.g., chlorpromazine , fluphenazine , haloperidol , loxapine , perphenazine , pimozide , pipamperone , prochlorperazine , setoperone , spiperone , spiramide , thioridazine , thiothixene , trifluoperazine )
Volinanserin
Xylamidine
Yohimbine
5-HT2B
Agonists: 4-Methylaminorex
Aminorex
Amphetamines (e.g., chlorphentermine , cloforex , dexfenfluramine , fenfluramine , levofenfluramine , norfenfluramine )
BW-723C86
DOx (e.g., DOB , DOC , DOI , DOM )
Ergolines (e.g., cabergoline , dihydroergocryptine , dihydroergotamine , ergotamine , methylergometrine (methylergonovine) , methysergide , pergolide )
Lorcaserin
MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA )
Piperazines (e.g., TFMPP )
PNU-22394
Ro60-0175
Serotonin (5-HT)
Tryptamines (e.g., 5-BT , 5-CT , 5-MT , α-Me-5-HT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine )
Antagonists: Agomelatine
Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , cariprazine , clozapine , N-desalkylquetiapine (norquetiapine) , N-desmethylclozapine (norclozapine) , olanzapine , pipamperone , quetiapine , risperidone , ziprasidone )
Cyproheptadine
EGIS-7625
Ergolines (e.g., amesergide , bromocriptine , lisuride , LY-53857 , LY-272015 , mesulergine )
Ketanserin
LY-393558
mCPP
Metadoxine
Metitepine (methiothepin)
Pirenperone
Pizotifen
Propranolol
PRX-08066
Rauwolscine
Ritanserin
RS-127445
Sarpogrelate
SB-200646
SB-204741
SB-206553
SB-215505
SB-221284
SB-228357
SDZ SER-082
Tegaserod
Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine )
Trazodone
Typical antipsychotics (e.g., chlorpromazine )
TIK-301
Yohimbine
5-HT2C
Agonists: 2Cs (e.g., 2C-B , 2C-E , 2C-I , 2C-T-2 , 2C-T-7 , 2C-T-21 )
5-Methoxytryptamines (5-MeO-DET , 5-MeO-DiPT , 5-MeO-DMT , 5-MeO-DPT , 5-MT )
α-Alkyltryptamines (e.g., 5-Cl-αMT , 5-Fl-αMT , 5-MeO-αET , 5-MeO-αMT , α-Me-5-HT , αET , αMT )
A-372159
AL-38022A
Alstonine
CP-809101
Dimemebfe
DOx (e.g., DOB , DOC , DOI , DOM )
Ergolines (e.g., ALD-52 , cabergoline , dihydroergotamine , ergine (LSA) , ergotamine , lisuride , LA-SS-Az , LSB , LSD , LSD-Pip , LSH , LSP , pergolide )
Flumexadol
Lorcaserin
MDxx (e.g., MDA (tenamfetamine) , MDMA (midomafetamine) , MDOH , MMDA )
MK-212
ORG-12962
ORG-37684
Oxaflozane
PHA-57378
Phenethylamines (e.g., lophophine , mescaline )
Piperazines (e.g., aripiprazole , BZP , mCPP , quipazine , TFMPP )
PNU-22394
PNU-181731
Ro60-0175
Ro60-0213
Serotonin (5-HT)
Tryptamines (e.g., 5-BT , 5-CT , bufotenin , DET , DiPT , DMT , DPT , psilocin , psilocybin , tryptamine )
Vabicaserin
WAY-629
WAY-161503
YM-348
Antagonists: Adatanserin
Agomelatine
Atypical antipsychotics (e.g., asenapine , clorotepine , clozapine , fluperlapine , iloperidone , melperone , olanzapine , paliperidone , quetiapine , risperidone , sertindole , ziprasidone , zotepine )
Captodiame
CEPC
Cinanserin
Cyproheptadine
Deramciclane
Desmetramadol
Dotarizine
Eltoprazine
Ergolines (e.g., amesergide , bromocriptine , LY-53857 , LY-215,840 , mesulergine , metergoline , methysergide , sergolexole )
Etoperidone
Fluoxetine
FR-260010
Irindalone
Ketanserin
Ketotifen
Latrepirdine (dimebolin)
Medifoxamine
Metitepine (methiothepin)
Nefazodone
Pirenperone
Pizotifen
Propranolol
Ritanserin
RS-102221
S-14671
SB-200646
SB-206553
SB-221284
SB-228357
SB-242084
SB-243213
SDZ SER-082
Tedatioxetine
Tetracyclic antidepressants (e.g., amoxapine , aptazapine , esmirtazapine , maprotiline , mianserin , mirtazapine )
TIK-301
Tramadol
Trazodone
Tricyclic antidepressants (e.g., amitriptyline , nortriptyline )
Typical antipsychotics (e.g., chlorpromazine , loxapine , pimozide , pipamperone , thioridazine )
Xylamidine
5-HT3 –7
5-HT3
Agonists: Alcohols (e.g., butanol , ethanol (alcohol) , trichloroethanol )
m-CPBG
Phenylbiguanide
Piperazines (e.g., BZP , mCPP , quipazine )
RS-56812
Serotonin (5-HT)
SR-57227
SR-57227A
Tryptamines (e.g., 2-Me-5-HT , 5-CT , bufotenidine (5-HTQ) )
Volatiles/gases (e.g., halothane , isoflurane , toluene , trichloroethane )
YM-31636
Antagonists: Alosetron
Anpirtoline
Arazasetron
AS-8112
Atypical antipsychotics (e.g., clozapine , olanzapine , quetiapine )
Azasetron
Batanopride
Bemesetron (MDL-72222)
Bupropion
Cilansetron
CSP-2503
Dazopride
Dolasetron
Galanolactone
Granisetron
Hydroxybupropion
Lerisetron
Memantine
Ondansetron
Palonosetron
Ramosetron
Renzapride
Ricasetron
Tedatioxetine
Tetracyclic antidepressants (e.g., amoxapine , mianserin , mirtazapine )
Thujone
Tropanserin
Tropisetron
Typical antipsychotics (e.g., loxapine )
Volatiles/gases (e.g., nitrous oxide , sevoflurane , xenon )
Vortioxetine
Zacopride
Zatosetron
5-HT4
5-HT5A
5-HT6
Agonists: Ergolines (e.g., dihydroergocryptine , dihydroergotamine , ergotamine , lisuride , LSD , mesulergine , metergoline , methysergide )
Hypidone
Serotonin (5-HT)
Tryptamines (e.g., 2-Me-5-HT , 5-BT , 5-CT , 5-MT , Bufotenin , E-6801 , E-6837 , EMD-386088 , EMDT , LY-586713 , N-Me-5-HT , ST-1936 , tryptamine )
WAY-181187
WAY-208466
Antagonists: ABT-354
Atypical antipsychotics (e.g., aripiprazole , asenapine , clorotepine , clozapine , fluperlapine , iloperidone , olanzapine , tiospirone )
AVN-101
AVN-211
AVN-322
AVN-397
BGC20-760
BVT-5182
BVT-74316
Cerlapirdine
EGIS-12,233
GW-742457
Idalopirdine
Ketanserin
Landipirdine
Latrepirdine (dimebolin)
Masupirdine
Metitepine (methiothepin)
MS-245
PRX-07034
Ritanserin
Ro 04-6790
Ro 63-0563
SB-258585
SB-271046
SB-357134
SB-399885
SB-742457
Tetracyclic antidepressants (e.g., amoxapine , mianserin )
Tricyclic antidepressants (e.g., amitriptyline , clomipramine , doxepin , nortriptyline )
Typical antipsychotics (e.g., chlorpromazine , loxapine )
5-HT7
Antagonists: Atypical antipsychotics (e.g., amisulpride , aripiprazole , asenapine , brexpiprazole , clorotepine , clozapine , fluperlapine , olanzapine , risperidone , sertindole , tiospirone , ziprasidone , zotepine )
Butaclamol
DR-4485
EGIS-12,233
Ergolines (e.g., 2-Br-LSD (BOL-148) , amesergide , bromocriptine , cabergoline , dihydroergotamine , ergotamine , LY-53857 , LY-215,840 , mesulergine , metergoline , methysergide , sergolexole )
JNJ-18038683
Ketanserin
LY-215,840
Metitepine (methiothepin)
Ritanserin
SB-258719
SB-258741
SB-269970
SB-656104
SB-656104A
SB-691673
SLV-313
SLV-314
Spiperone
SSR-181507
Tetracyclic antidepressants (e.g., amoxapine , maprotiline , mianserin , mirtazapine )
Tricyclic antidepressants (e.g., amitriptyline , clomipramine , imipramine )
Typical antipsychotics (e.g., acetophenazine , chlorpromazine , chlorprothixene , fluphenazine , loxapine , pimozide )
Vortioxetine